Question

Place these steps of the insulin signaling pathway in the correct order from insultin is secreted to glucose enters the cell. Place all eight steps. The abbreviation PIP2 is used for phosphatidylinositol 4,5-bisphosphate; PIP3 is used for phosphatidylinositol 3,4,5-trisphosphate.1. Activation of Akt2. Binding of insulin to the alpha subunit of the insulin receptor3. Phosphorylation of IRS proteins4. Conversion of PIP2 to PIP35. Glut4 receptors transported to cell membrane6. Phosphorylation of phosphinositide 3-kinase (PI-3K)7. Activation of PIP3-dependent protein kinase B (PDK1)8. Activation of insulin receptor tyrosine kinase

Answer 1

Answer:

1. Binding of insulin to the alpha subunit of the insulin receptor

2. Activation of insulin receptor tyrosine kinase

3. Phosphorylation of IRS proteins

4. Activation of PIP3-dependent protein kinase B (PDK1)

5. Phosphorylation of phosphinositide 3-kinase (PI-3K)

6. Conversion of PIP2 to PIP3

7. Activation of Akt

8. Glut4 receptors transported to cell membrane