Question

An enhancer may increase the frequency of transcription initiation for its associated gene when… (indicate true or false for each statement and explain your answer…) A. …it is located 1000 nucleotides upstream of the gene’s core promoter. B. ...it is located 1000 nucleotides downstream of the gene’s core promoter. C. …it is in the gene’s coding region.

Answer 1

Answer:

it is located 1000 nucleotides upstream of the gene’s core promoter - true

it is located 1000 nucleotides downstream of the gene’s core promoter- true

it is in the gene’s coding region - False

Explanation:

These enhancers are located 50 or more kilobases from the promoter they controlled upstream from a promoter, downstream from a promoter within an intron, or even downstream from the final exon of a gene which can be thousands of bp away from the gene's core promoter and can also occur thousands of nucleotides away from the gene's core promoter needing the activity of a DNA -bending protein that binds to the enhancer changing the shape of the DNA and allow interactions between the activators and transcription factors.