Question

A cell accumulates several mutations in the genes that regulate its cell cycle. As a result, the cell no longer responds to internal and external cues that had prevented it from dividing. What is the most likely consequence of these mutations?

Answer 1

ANSWER: CANCER DEVELOPMENT

EXPLANATION:

Tumor suppressor genes (TSGs) are genes that regulates the cell cycle of a cell (i.e the cell division and replication). In other words, TSGs encodes protein that act as control or regulator of cell growth.

However, when there is an alteration in the genetic sequence (mutation) of the TSGs, this make the cell not to respond to cues that had been regulating it growth.

Thus, when cell growth is not regulated, it results to runaway or abnormal cell growth (i.e multiple folds cell division and replication), in other word referred to as “cancer”.

Answer 2

Answer:

The consequence of this is the manifestation of benign and / or malignant neoplasms.

The more likely that the more mutations accumulate in the cell, the greater the risk of malignancy, therefore, the greater the risk that it is a cancer.

Mutations of cell division for malignancy or cancer to occur would be explained below

Explanation:

For a cell to become malignant and begin to proliferate excessively with malignant properties that lead to the formation of cancer, it is necessary for many genes of cell division to mutate, not just one ... These are:

Genes that inhibit cell proliferation, the presence of the passage from protoncogene to oncogene, genes that regulate cell division and finally stimulators of cell multiplication.

In advanced stages of cancer, mutations are increasing and even the presence of genes promoting angiogenesis to provide good nutrition to this malignant uncontrolled tissue has been shown.