"To help foster peace and economic collaboration among European nations" is the one among the following choices given in the question that <span>best describes the purpose of the European Union. The correct option among all the options that are given in the question is the first option or option "A". </span>
<span>The correct answer is CONNECTIVE. Cartilage, one of the types of connective tissue found in the body. It is a smoother and more resilient and flexible type of connective tissue than other types found in the human body and acts as a rubber-like padding at the ends of many of the bones and joints in the body. It is also a structural component of the ears and nose.</span>
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
carries the genetic information copied from DNA in the form of a series of three-base code “words,” each of which specifies a particular amino acid.