I think the answer to this one is A.
Clovis technological complex - Distinctive spear points
Neanderthals extinct in Europe - Bones stop appearing in the archaelogical record
Earliest modern humans emerge - Their skulls found at Herto, Ethiopia
Homo sapiens cross into Asia - Tools found at Jwalapuran, India
The best and most correct answer among the choices provided by your question is the first choice.
The map describes the Louisiana Purchase.
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I think both were met with violent resistance in the South.