Nucleus would be your answer
There are many ways humans can reduce the amount of endangered and extinct species. However, I would say by reducing pollution and logging/mining. Nearly 318 species have become extinct due to pollution. The reduction of carbon emissions would be a good way to curb the amount of pollution produced by humans.
Hey this is late, but if an organ fails, like for example the kidney fails right? So then it affects the heart. and so on, because the kidney helps clean the blood and your body needs blood.