Answer: The Magdeburg hemispheres are a pair of large copper hemispheres, with mating rims. They were used to demonstrate the power of atmospheric pressure. When the rims were sealed with grease and the air was pumped out, the sphere contained a vacuum and could not be pulled apart by teams of horses.
Explanation:
The dark brown color of a penny is most likely oxidation, which occurs when the copper in the penny comes in contact with oxygen.<span> </span>
Answer:
SADSFADVADVADADVADVADVADVADVADVADVADADADSVADVADADSVADVADAVVVVVVVVVVVVVVVVVVVVVVVVVVVV
Explanation:
Answer:
I think its organic material from plants and animals
Explanation
Edge 2020
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
#SPJ4
