Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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The correct formulae is CCl4
Answer:
xecr tbyununybt y 7nbytvthhbbhd r f
Proteins are important biomolecules. Proteins are synthesized and often packaged for secretion into other cells within an organism. A variety of organelles play a role in producing, packaging, and moving proteins.
Organelles of Eukaryotic Cells
Organelle Function
Nucleus The “brains” of the cell, the nucleus directs cell activities and contains genetic material called chromosomes made of DNA.
Mitochondria Make energy out of food
Ribosomes Make protein
Golgi Apparatus Make, process and package proteins
Answer:
the tissue in plants that conducts water and nutrients upwards from the root
