For a substrate to bind to a particular enzyme what do you need

1 answer:

4 0

The enzyme’s active site binds to the substrate. Since enzymes are proteins, this site is composed of a unique combination of amino acid residues (side chains or R groups). Each amino acid residue can be large or small; weakly acidic or basic; hydrophilic or hydrophobic; and positively-charged, negatively-charged, or neutral. The positions, sequences, structures, and properties of these residues create a very specific chemical environment within the active site. A specific chemical substrate matches this site like a jigsaw puzzle piece and makes the enzyme specific to its substrate.

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Different mRNA molecules can have poly-A tails of different lengths. Considering the purpose of adding the poly-A tail (from the

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Answer: Then the longer it is, the more it protects against degradation. Proteins that are needed over a long period of time come from a long tailed mRNA.

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Messenger RNA is synthesized in the cell nucleus in eukaryotes from the process called DNA transcription. In most cases, once this messenger RNA has been synthesized, it must be matured (RNA maturation). This involves the removal of intercalary sequences called non-coding introns from the protein to be synthesized. Then, the addition of a structure called CAP to the 5' end, which is a modified guanine nucleotide needed for the normal process of DNA transplantation and maintaining its stability. This is critical for proper recognition and access of the ribosome. Also, polyadenylation which is the addition of the sequence called Poly-A to the 3' end. The Poly-A sequence is made up of several adenine molecules and is located at about 20-30 bp towards the tail (AAPAA sequence) or polyadenylation signal, which protects the end of the mRNA. The polyadenylation helps to increase the period of the message, so that the transcription lasts longer in the cell and therefore more protein is translated and produced.

This mature messenger RNA is transferred to the cell's cytoplasm, in the case of eukaryotes, through pores in the nuclear membrane. The messenger RNA in the cytoplasm is coupled to the ribosomes, which are the machinery in charge of protein synthesis. However, after a certain amount of time the mRNA is degraded into its component nucleotides, usually with the help of ribonucleases. So, an mRNA with a short tail will have a shorter lifespan.

Then, proteins that are needed over a long period of time come from a long tailed mRNA. And proteins that are briefly nedded come from a short tailed mRNA. This is because, as explained, the Poly-A tail serves to protect the mRNA molecule from degradation. So, then the longer it is, the more it protects against degradation.

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