Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
When doing venipuncture on an elderly client whose veins are hard to find, the nurse should touch the skin around the insertion site.
Location for Venipuncture:
- The two veins most frequently utilized for venipuncture are -
- the cephalic and
- median cubital veins.
- Possible locations include the dorsum of the arm's basilic vein or the dorsal veins of the hands.
- The basilic vein, which is found on the pinkie side of the arm and is adjacent to the brachial arteries and median nerve, must only be utilized if there are no other more noticeable arm veins, due to its close closeness to both.
- Only in extreme cases can veins in the ankle and foot be used. Avoid touching the veins on the inside of the wrist. A few additional websites ought to be avoided as well.
Learn more about venipuncture here:
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Answer:
I do not agree with Heather’s definition of homeostasis because, by definition, homeostasis is defined as the ability of a body to create comfortable conditions by being at equilibrium or stabilizing itself internally whenever there are changes externally/outside the body. With regard to homeostasis, the room temperature of the internal part of the body, as with many other things in the body, is dynamic and does not stay at one place when external conditions change—it changes in order to maintain balance or equilibrium; hence, I do not agree with Heather’s definition of homeostasis.
Answer:
The lungs are not equal in size. The right lung is shorter, because the liver sits high, tucked under the rib cage, but it is broader/wider than the left. Each lung is separated into lobes branching off the main bronchus the right lung has three lobes, while the left has only two lobes. That's why the left lung and the right lung are difference.
Explanation:
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