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The de ritis ratio is the calculation of ast/alt and is used for evaluating liver disease. the Enzyme Ratios be when ethanol-related liver disease is expected
The AST/ALT ratio, according to De Ritis, is a useful indicator of the cause of hepatitis (for instance, acute viral hepatitis), and Wroblewski backed up and elaborated on his findings. In the decades that followed, more research employing improved transaminase techniques continued to support the initial findings.
Other enzyme ratios, such as the sum of serum AST+ALT activities divided by the serum glutamate dehydrogenase activity (GDH) as proposed by Schmidt and Schmidt and the ratio of GDH to ALT as proposed by Forster et al.
, which is thought to be less reliable, have also been suggested to have similar utility for the identification of viral hepatitis
The ALT to alkaline phosphatase (ALP) activity ratio was found to be more effective than the sum of its parts by Aronsen et al.
Only the cytoplasm of hepatocytes contain ALT, whereas
Learn more about Enzyme Ratios here.
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