<span>Both Mepolizumab and reslizumab bind to interleukin-5 (IL-5), a key cytokine responsible for the differentiation, maturation, and activation of human eosinophils. Both antibodies bind to IL-5 and prevents binding to the interleukin 5 receptor alpha subunit, on the surface of eosinophil white blood cells. When these antibodies bind to IL-5, they stimulates B cell growth and increases immunoglobulin secretion, and this reduces the survival of eosinophils. Eosinophils, along with basophils and mast cells, are important mediators of allergic responses and severe asthmas.</span>
Interleukin-5 (IL-5). IL-5 is responsible for the recruitment and maturation of eosinophil. Eosinophils on the other hand are majorly involved in the inflammatory response in asthma- characterised by narrowing of the airways. Mepolizumab and reslizumab are, therefore, anti-IL-5
The organs are known as Vestigial organs. The evolution from land-dwelling animal to the marine animals has led whales as well as dolphins, to lose hind limbs. The pelvic and leg bone serves no purpose in them and just provide the anchorage to muscles
the first answer as blood needs to be oxygenated to be passes round the body then when its deoxgenated it will return to the heart to be pumped around the body again
