Answer:
Sigma factors bind to the promoter region of a particular gene and facilitating the binding of RNA Polymerase to the promoter region (formation of the RNA polymerase holoenzyme complex) in order initiate transcription of the gene.
Put simply - Helps RNA Polymerase do it's job.
The commonly used site to feel a pulse is radial artery on the wrist, the point where radial artery approaches the wrist present at the middle of wrist.
When we placed our fingers in the middle of wrist, we can feel the pulse wave. That is 72 beats per minutes. The radial artery is the site of insertion of the arterial line, for monitoring the blood pressure. It is selected because it is accessible due to the low incidence of the complications such as thrombosis.
The pressure of the blood is always high in the arteries comparative to the veins, usually arteries are present deep in the body, the radial artery in only artery that approaches the skin. Hence, it is used to monitoring the pulses.
To learn more about arteries here
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The main function of the nephron is to filter wastes out of the body and the re-absorption of substances required by the body.
The nephron also has components that have specific functions. There are about 1 million nephrons in one kidney
