The hypothesis by Coleman was that the product of the ob+ gene was the appetite suppressing hormone. Hence, the homozygous ob/ob mutant are in a position to synthesize that hormone, and its circulating level would be zero. He also hypothesized that the product of the db+ gene was the receptor for the appetite-suppressing hormone. Thus, the homozygous db/db mutant would be able to synthesize the hormone but would not be in a position to respond to it. It would eat excessively and produce large amounts of body fat, which in turn would produce large amounts of appetite-suppressing hormone . In the absence of a receptor, the db/db mutant's hormone level would remain abnormally high.
Coleman's hypothesis were confirmed when the precise functions of the ob+ and db+ genes were determined. The peptide hormone encoded by the ob+ gene was named Leptin.
"DNA double helix, nucleosome, coils, supercoils, chromosome" is the correct way of placing the following terms <span>in the correct order from smallest to largest. There is no other way to sort or arrange the given items from the smallest to largest, other than that written in the answer. i hope the answer helped you.</span>
I mean a parent would get worried at an injury but head and spinal injuries can be very serious and sometimes hard to catch. Like brain bleeds and etc
