If you let them get past your boundaries they wont know where to stop. The right place to stop on a first date is maybe a peck on the lips or cheek.
High blood pressure medications works in different ways and can have an effect in different time periods. In general you should allow about 2 - 3 weeks to see a full effect from a medication. This full effect is not only what the medication does, but how your system reacts to the drug and adjusts to the changes.
Oxygen enters the lungs, then passes through the alveoli and into the blood.