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Explana
There are no disadvantages to an individual with the peppered moth.<span />
Answer:
Cultivate prime grain and with timely care
Because they were passed down from a common ancestor, homologous structures are those found in related organisms that are comparable. These structures might or might not serve the same purpose in their offspring. The hands of various different mammals are depicted in the figure below. The basic skeletal structure of each is the same.
What is offsrping?
a person, animal, or plant's offspring or progeny is the result of reproduction. Parental transmission of the illness can affect children, a human or animal's direct offspring; a person born of parents gave birth to a lone child.
Creating offspring is considered reproduction. Reproduction comes in two basic forms: sexual reproduction and asexual reproduction. A sexually reproducing creature integrates the genetic material of both parents to create a genetically distinct individual. Asexual reproduction involves the self-replication of one parent to create genetically identical kids.
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Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
