Numerous degenerative neurological conditions, most notably Parkinson's disease, have been linked to an excessive buildup of alpha synuclein (a-syn) in the brain. Intraneuronal inclusions, often known as Lewy bodies, are neuropathological characteristics seen in Parkinson's disease, Lewy body dementia, and other synucleopathies. The aggregation of a-syn is their main structural component. A-syn accumulation, aggregation, and ensuing Lewy body formation can be attributed to a variety of biological processes. These include genetic changes in parkin, synuclein, or the deubiquitinating enzyme ubiquitin C-terminal hydrolase (UCH-L1), which results in less efficient removal of a-syn via the ubiquitin proteasomal pathway (UPP). Additionally, environmental variables and an age-related decline in antioxidant defense mechanisms that heighten oxidative stress and can have an impact on the formation or clearance of a-syn are intracellular insults.
We focused on changes in the aggregation and clearance of a-syn as impacted by the UPP and the oxidative stress pathways in our dynamic models of a-syn processing in both normal and various disease states. A free radical profile similar to that observed in vivo after exposure to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is produced during simulation of enhanced oxidative stress (MPTP). To replicate the kinetics of a-syn that correlates to the neuropathology reported for the sporadic and hereditary types of Parkinson's disease, different model parameters of oxidative stress, UPP failure, or both routes are used. With the use of this in silico model, it is possible to evaluate the kinetics of pathway elements and more accurately identify and validate key pharmaceutical targets.
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Answer:
many
pollution by dumping chemical that are harmful to the animals
littering by plastic
accidentally introducing invasive species
over fishing
it lowers the biodiversity of the aquatic ecosystems living there
Explanation:
Answer:
Heterozygous for the gene
Explanation:
Alleles are the possible alternative forms of a gene. An organism having two identical alleles of a gene is said to be homozygous for that gene. On the other hand, an organism having two dissimilar alleles for a gene is heterozygous for that gene.
For example, let's suppose that I^A and I^B are the two alleles for ABO blood type in humans. Here, an individual with one copy of I^A and one copy of I^B would be heterozygous for ABO blood type. On the other hand, genotypes I^AI^A and I^BI^B are homozygous for the ABO blood type gene.
-Water evaporates and condenses into clouds, then the clouds are blown over the ocean, and it rains.
-Water from a mountain flows down and into a river. The river empties into an ocean.
Rotary, oscillating, linear, reciprocating
