The intermediate color or rather condition, in this case "roan", is a result of two alleles being codominant. Codominance occurs when the phenotype (or the physical expression of the gene) of a heterozygote individual expresses both the alleles in a pair of genes. In the given situation, both parents are homozygotes.
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<span>To have the disease, males need only one copy of the affected X.</span>
So, the frequency of affected males will be the frequency
of the disease allele = 0.02
Females must inherit two copies and be
homozygotes, so the frequency of affected females will be the double of frequency
of the disease allele = (0.02)
Since the ratio between female and male is 50:50
that is half of the population is male and half female
<span>Then the overall frequency of the disease will be,</span>
(0.5) (0.02) + (0.5) (0.0004) = 0.01 + 0.0002
<span>Thus, the frequency of affected
individuals in this population is <span>0.0102.</span></span>
