1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Leto [7]
2 years ago
14

A mechanism by which cancer cells can evade an immune response involves an alteration in the amount of MIC on the cell surface b

y _________. Group of answer choices cleavage of MIC at the cell surface by a protease decreasing the level of MIC transcription switching from a transmembrane form of MIC to a secreted form cytosolic degradation of MIC in proteasomes alternative mRNA splicing resulting in a truncated form of MIC that is no longer able to bind to NKG2D
Biology
1 answer:
kvasek [131]2 years ago
8 0

Answer:

cleavage of MIC at the cell surface by a protease

Explanation:

The immune system refers to a complex network of cells and proteins that function to eliminate potentially tumorigenic cells on a daily basis. However, cancer cells show mechanisms in order to escape immune responses. MHC class I chain-related proteins A and B (MICA and MICB) are expressed in normal and tumorigenic cells where they act as ligands of the NKG2D receptor. The expression level of these proteins (MICA and MICB) is finely regulated by the activity of metalloproteinases (i.e., by protease-mediated cleavage), but this mechanism is altered in cancer cells. Recently, drug therapies that stimulate NKG2D mediated tumor destruction by reducing the cleavage of MICA and MICB from the surface of cancer cells have been developed.

You might be interested in
A man who smokes heavily has developed lung cancer. The tobacco smoke has caused mutations in some of the cells in his lungs, ma
Naya [18.7K]

Answer:

The correct answer is: B. If he inherited a mutation which made him more susceptible to lung cancer, it may have been present in some of the gametes he produced and passed to his children.

Explanation:

  • The inheritance of genes from the parents to the offspring is mediated by the germinal cells or sex cells or gametes of the parents.
  • The genetic material present in the somatic cells of the parents are not transmitted to the offspring.
  • In the given case, the man who develops lung cancer generates some tobacco smoke induced mutations in some of the cells of his lungs.
  • The cells of the lungs are type up of somatic cells. Hence, any mutations in the genome of these cells will never be transmitted to the offspring.
  • Therefore, the children of the man will never become prone to develop lung cancer due to development of mutations in the lung cells of the man.
  • However, if the man has inherited any mutation from his parents which can increase the risk of development of lung cancer, then these mutations will be present in his germinal cells and also in some of his gametes.
  • Now, if a child is born due to the fusion of the the maternal gamete with one of these mutated paternal gametes, there is an increased chance of developing lung cancer in the child, irrespective of the fact whether he is a smoker or a non-smoker.

3 0
3 years ago
Identify the substances that can readily pass through the inner mitochondrial membrane.
KIM [24]

Answer:

A,C E

Explanation:

The inner membrane of the mitochondria separate the matrix of the mitochondria from the cytosol(inner membrane space.). It is invaginated  folded inwards  to form the critae. This is an adaptive feature to increase the surface area for biochemical reaction in the mitochondria.

The invagination gives two compartments the inner mitochondria also creates the outer intermembrane space and the inner matrix

These are the substances that can pass freely the inner membrane of the mitochondria.Pyruvate and H+ can not pass through.Specifically,it is not preamble to H+ because, hydrogen ions are needed to generate the electrochemical gradients needed for the chemical energy  for phosphorylation of ADP by  P to form ATPs by the enzyme ATPase synthase.If the inner membrane is permeable to H+ the electochemical gradient will not be produced, and therefore ATPs productions stops.

O2 needs to pass through the inner membrane because it it the final electron acceptor. Therefore if not allowed to pass through oxidative phosphorylation  and ETC will nor occur.

CO2 must pass through because its accumulation will increase the acidity of the inner  mitochondria

5 0
3 years ago
What is the answer ??
horrorfan [7]

Answer:

take a pick closer

5 0
3 years ago
Choose the statement that best describes the Americans who served in Vietnam.
tatyana61 [14]
The statement that best describes the Americans who served in the Vietnam war was most of the US soldiers were all young, working class volunteers. The correct answer is D. 
8 0
2 years ago
Give two similarities and two differences between gymnosperms and angiosperms.
kakasveta [241]

<span>Similarities</span> between Gymnospermes and Angiospermes:


<span>·         </span>Having seed-Gymnospermes and Angiospermes are types of plants bear seeds. They belong to a single class known as Spermatophyta. Spermatophyta or seed plants are those <span>plants that produce seeds.</span>

<span>·         </span>Diferentiation- The sporophyte (diploid multicellular stage in the life cycle of a plant) of both,<span> Gymnospermes and Angiospermes,</span> is differentiated into root, stem, and leaves.


Differences between Gymnospermes and Angiospermes:

 

<span>·         </span>Seed-Although both have seeds, differences between them are huge. Gymnospermes have bare, non-encased seeds. The term "gymnosperm"  in Greek means "naked seeds". On the other hand, seeds of Angiospermes are enclosed within an ovary, usually in a fruit.

<span>·         </span>Pollination- In Gymnospermes, the pollination is by wind, unlike most Angiosperms, who use insects, mammals or birds.  Gymnosperm flowers are often difficult to spot because they are not out to attract flying pollinators.

7 0
3 years ago
Read 2 more answers
Other questions:
  • Jupiter, Saturn, Uranus, and Neptune are a known as ________. a. terrestrial planets c. dwarfs b. ringed giants d. gas giants Pl
    5·2 answers
  • Basaltic magma is very fluid. What type of volcano and eruption would basaltic magma most likely produce?
    7·2 answers
  • A carbon atom can bond with other atoms in a variety of ways. Wich set of bonds would a typical carbon atom in a compound
    11·1 answer
  • In the genetic drift analogy of a drunk man on a train platform, the width of the platform is analogous to what
    5·1 answer
  • Most food chains have no more than six organisms. why is there a limit to the number of links in a food chain?
    11·1 answer
  • Your science teacher asks you to build a model of a cell. The model should look like a city, and buildings in the city should re
    9·2 answers
  • What component of the brain makes teenagers seek constant validation by sharing selfies with friends on social media?
    12·1 answer
  • One serving of an ice cream topping provides 40% DV for saturated fat. The ingredient list reads as follows: Sugar, corn oil, co
    13·1 answer
  • What is gene therapy?
    11·2 answers
  • Time Span of the renewability of fuels is a major factor when considering what type of fuel to use in a project. Fossil fuels, i
    7·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!