The primary way in which Shay's Rebellion showcased the economic issues of the age was that it proved that the federal government lacked any adequate means to put down the rebellion, and that there was no central system of taxation, which was needed to pay of war debts.
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They're connected because they both led to the booming production of cotton latter on in the United States after Slater the Trader exposed all secrets of production of the British.
Spain (and Portugal) wanted to find a sea route to Asia because Portugal did not share trade routes with Asia and Europe (no Meditteranean Ports), Spain wanted to Spread Christianity, and both countries wanted to find more trade.