Answer:The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The structure shows GSK1264 buried between the IN C-terminal domain (CTD) and the catalytic core domain. In the crystal lattice, the interacting domains are contributed by two different dimers so that IN forms an open polymer mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structurally disordered. Engineered amino acid substitutions at the inhibitor interface blocked ALLINI-induced multimerization. HIV escape mutants with reduced sensitivity to ALLINIs commonly altered amino acids at or near the inhibitor-bound interface, and these substitutions also diminished IN multimerization.
Explanation:
Answer: An <em>IP</em> address is commonly referred to as an accredited series of numbers, disjointed by periods, this eventually provides an address on web. In laymen terms, an IP address is commonly known as a numerical label accredited to a device that is connected to a network which uses the IP for communication.
Answer:
<bold> Hm ok, what is the question? </bold>
Answer:
TRUE
Explanation:
In telecommunication and computing, there are different units of data storage. The most commonly used units are the bit and the byte.
A bit is the capacity of the system having only two states.
Whereas, the byte, also known as octet, is equal to eight bits. The unit symbol for Byte is B. In many computers, it is the smallest addressable unit of memory.
Therefore, <u>the given statement is TRUE</u>.
Answer: tried using stack over flow and GitHub. The have most of the codes for everything
Explanation:
