Answer:
Phase III
Explanation:
The given condition fall in the trial phase (Phase III) of cinical study which aims to:
- Determine drug's effectiveness (primary goal)
- Determine long-term drug safety
- Confirm findings
In Phase III, randomised, double-blind, placebo-controlled, parallel group study is majorly to evaluate the efficacy and safety of placebo in episodic migraine prevention in children (6 to < 12 years of age) and adolescents (12 to < 18 years of age).
The trial consists of four phases: screening; double-blind therapy period for 24 weeks in which placebo or Erenumab is given to subject as dose 1, dose 2 or dose 3 (based on the participant's body weight) once a month via subcutaneous injection; optional dose level blinded extension phase (40 weeks) which involves subjects recieve dose1, 2 and 3 of placebo, and at last it follows a safety follow-up phase for 12 weeks (after 16 weeks of the last dose of investigational drug).
Hence, the clinical phase is phase III.
Earthquake, volcano and continental shifts
<u>Answer:</u>
<em>The intertidal zone is a region of extreme conditions and the organisms should have special mechanisms to cope up with the extreme conditions.
</em>
<u>Explanation:</u>
Low tides expose an intertidal zone to air while high tides cover the intertidal zone with ocean water. When exposed to air the intertidal region is <em>directly exposed to the sun and there will be high temperature. </em>
Thus the animals have to cope up with the extreme heat and also have to face colder environment when under the sea. <em>Since there is change in salinity the organisms have to handle this as well.</em>
Some animals with shells close their shell tightly to seal moisture. Animals like <em>snails and crabs have thick outer covering to prevent water loss by evaporation. </em>
Organisms like leaf barnacles cluster together to avoid individual exposure. <em>Animals like sea stars cling to the rocks to avoid being washed away by the waves.
</em>
Answer:
the waters acts as a solvent for chemical reactions and also helps transport dissolved compounds in and out of cells.
