The answer you're probably looking for is:
The Stamp Act of 1765 was significant in the sense that it was the first direct tax imposed on American colonists (So, 
would most likely be the answer that you're looking for to this question, that you have asked
Answer:
the Balfour Declaration
the British Mandate
Britain's restriction on Jewish immigration
the end of World War II and Holocaust
the creation of the independent State of Israel
Explanation:
Brown v. Board of Education of Topeka, 347 U.S. 483 (1954), was a landmark United States Supreme Court case in which the Court declared state laws establishing separate public schools for black and white students to be unconstitutional. The decision effectively overturned the Plessy v. Ferguson decision of 1896, which allowed state-sponsored segregation, insofar as it applied to public education.
The correct answer is - A war between the colonies and Britain.
After the Declaration of Independence and what it actually meant and encouraged the people in the colonies to do, the expected reaction from the British Empire was that it will try to use military force in order to keep the colonies under its control. And the expectations were true, as the British did launched a military campaign against the rebelling colonies, but the Americans were prepared for this and managed to withstand their ground and gained their desired independence, and that was a major blow for the British, especially from economic perspective.
