When the pH is not balanced between the extracellular and intracellular environment, the cell could go into shock, that is why in the face of the minimal differences in pH between the internal or external environment, the proton pump is activated, this is how the hydrogen ion or positively charged protons cross the membrane and indirectly generate ATP molecules.
It would be any mutation of the DNA or mRNA mutations in sequences that control the cell cycle because mutations are caused for an error in DNA since DNA contains all your traits and genes.
