The tertiary structure of a protein includes the overall three-dimensional arrangement of all the atoms of a protein. The amino acid residue located far apart from each other in a protein and have different secondary structures interact and determine the overall folding pattern of the proteins.
Therefore, when any condition such as mad-cow disease causes misfolding of protein, it affects the tertiary structure of the proteins since the overall folding pattern of the protein reflects its tertiary structure.
the ATP synthase complex is located in the inner membrane of mitochondria, with the ATP synthesis reaction occurring on the membrane side toward matrix compartment
