The battle of 1812 was the war of 1812
To forbade colonial settlements west of the Appalachian mountains
Some of the diseases were new and treatments were ineffective. Malaria was deadly to many new colonists, especially in the Southern colonies. Of newly arrived men, over one-fourth of the Anglican missionaries died within five years of their arrival in the Carolinas. Mortality was high for infants and small children, especially for diphtheria, small pox, yellow fever, and malaria.
True of course these are very big issues around the world