The Appalachian Mountains lay west of the thirteen colonies. It formed a natural barrier between the colonies and all land to the west
The losses in the Middle East were staggering: the war not only ravaged the land and decimated armies, it destroyed whole societies and economies. In this way, the experience of World War I in the Middle East is perhaps more akin to the experience of World War II in Europe.
Extreme pro-slavery elements objected to it because it provided a precedent by which Congress had power to regulate slavery. Abolitionists opposed it because it allowed slavery to continue to spread in some of the areas.