Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer:
1.) stromatolites
2.) photosynthesis
3.) Ordovician
4.) Cambrian
5.) oxygen
6.) As Earth cooled, carbon dioxide dissolved in the early ocean. Cyanobacteria consumed carbon dioxide and converted it to oxygen. Methane was removed from the atmosphere as oxygen was produced, eventually leading to the Cambrian Explosion.
7.) Metabolic processes that use oxygen produce more energy than anaerobic metabolism. Simple diffusion of oxygen would limit the size of a multicellular eukaryote, but animals evolved ways to transport oxygen to their tissues, which permitted an increase in size.
Explanation:
From Penn
Answer:
Light dependent reaction and the Calvin cycle
Explanation:
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Answer:
A. single-gene
Explanation:
It is controlled by a single gene that has two alleles. The allele for a widow's peak is dominant over the allele for a hairline with no peak.
Answer:
agriculture
Explanation:
Slash-and-burn <u>agriculture</u>, method of cultivation in which forests are burned and cleared for planting. Slash-and-burn agriculture is often used by tropical-forest root-crop farmers in various parts of the world and by dry-rice cultivators of the forested hill country of Southeast Asia
