Potential group of answers choices refers to the functional
The reduced potential causes hundreds of <u>voltage-gated sodium</u> channels to open on that part of the cell membrane. The depolarization of the cell causes more of <u>voltage-gated sodium </u>channels to open in adjacent parts of the cell membrane. This begins the wave of of <u>depolarization</u> moving down the axon. Depolarization begins at the <u>axon hillock.</u>
Explanation:
When there is no neuron signaling it becomes polarized, termed as resting membrane potential (RMP) at a threshold voltage (around -55 mV), due to the action of the sodium-potassium pump and the potassium leak channels.
When a change in the RMP occurs, depolarization takes place which causes the voltage-gated sodium channels to open and sodium ions rush into the nerve cell which in turn will increase the voltage threshold to nearly around +40 mV and also charges the neuron positive. This depolarization moves down the axon. This increase in threshold stops the sodium influx and opens the potassium channels to rush the potassium out of the cell.
All these actions decrease the membrane potential leading to a wave of depolarization and going back to resting state. Depolarization begins depending upon the potential gradient at the axon hillock.
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If the live enzyme fructose 1,6- bisphosphatase defect is occured and this results in an abnormally high levels of lactate in the blood plasme this will result into the lactate will accumulate into the blood.
What is the work of fructose 1,6-biphosphatase enzyme?
In the liver, gluconeogenesis converts lactate to glucose. If FBPase-1 is defective, lactate cannot enter the gluconeogenic pathway in hepatocytes, building up in the blood.
A crucial enzyme in gluconeogenesis is fructose 1,6-bisphosphatase (FBPase). It is a possible target for drugs used to treat type II diabetes. Additionally, the protein is linked to a rare genetic metabolic disorder, and certain cancer cells lack the activity of the enzyme FBPase, which encourages glycolysis and aids in the Warburg effect.
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