The chemical reactions in the cell would not happen as fast and would require more energy to catalyze the reaction between the two reactants.
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Chemistry/ Example: Take breathing for example, when you breath you breath out carbon dioxide. The CO2 can't just leave like that and only 10% binds to hemoglobin. The rest turns into carbonic acid in your blood and its plasma. However, the acid is unstable, so it turns into bicarbonate and a dissociated proton (H). You have carbonic anhydrase that converts the two so you can breath out CO2; the carbonic acid separates into H2O and CO2. This process would take a LONG time without the enzyme-- CO2 build up, even minimal amounts it lethal.
Because they have no competitors in any echological niche
The expected symptom would be B. numbness
