accumulations of genetic mutations over time.
Genetic and epigenetic changes compound over time to cause cancer. While aging and chronic inflammation are the major causes of epigenetic changes, carcinogenic substances, UV radiation, and other conditions can also cause genetic changes. Our prior exposure levels and life history are reflected in the accumulation and patterns of changes in normal cells. The majority of accumulated changes are regarded as passengers, although they are linked to cancer drivers as they accumulate. Although only hypothesized for genetic changes, this has been demonstrated for aberrant DNA methylation. However, modern technology has made it possible to assess uncommon point mutations, and research has revealed that the rates of their accumulation do actually correspond with cancer risk.
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When supply is greater than demand!
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After age 50, bone breakdown (resorption) outpaces bone formation and bone loss often accelerates, particularly at the time of menopause.
What is Osteoporosis ?
Osteoporosis causes bones to become weak and brittle — so brittle that a fall or even mild stresses such as bending over or coughing can cause a fracture. Osteoporosis-related fractures most commonly occur in the hip, wrist or spine. Bone is living tissue that is constantly being broken down and replaced.
Osteoporosis is a disorder where your bones become brittle, fragile, and easily breakable as you age because certain minerals begin to leach out of them. Because estrogen, which helps keep bones strong, is lost during menopause, women over 50 are particularly at risk for osteoporosis.
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The answer to your question is homeostasis
