They use absolute dating methods, sometimes called numerical dating, to give rocks an actual date, or date range, ... However, there are radiometric dating methods that can be used on sedimentary rock, including luminescence dating
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sorry if it wrong
Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
<span>The ventricles are the part of the heart that are responsible for the pumping action to move blood throughout the body. Therefore, the muscles in the ventricles are much larger and thicker to do their job properly. The atrium only has to pump blood through an open valve (the tricuspid valve) into the right ventricle. There is much less resistance to this flow of blood so much less muscle is needed. </span>
The condition is which characteristics of atmosphere III is nitrogen-rich and oxygen-poor. Nitrogen-rich is one of the condition in which the atmosphere III characterizes. The other is oxygen-poor, is one of the condition characterizes atmosphere III. Nitrogen-rich material mostly called green because they are greenish in color. Oxygen-poor means the blood enters the RA or Right atrium or the upper chamber of the heart.
the area of the square is: 100
the area of the circle is: 78.5
i THINK if you subtract it, it will be 21.5
