Answer:
the pathway will be under-expressed.
- the alpha subunit helps to bind with either GDP or GTP. when the α subunit is bound with GDP, it will be bound to β and γ subunits and thus forms an inactive state for G-protein.
- when the alpha subunit binds with the GTP, it becomes activated and dissociates β and γ subunits.
if G-protein Coupled Receptor is unable from dissociating β and γ subunits, then the pathway will go under expression.
The chemical qualities of the alpha subunit allow it to bind easily to one of two guanine subunits, GDP or GTP. The protein thus has two functional formations. When GDP is bound to the alpha subunit, the alpha subunit remains bound to the beta-gamma subunit to form an inactive trimeric protein.
G-proteins, cAMP, and Ion Channel Opening. The alpha subunit activates adenylate cyclase, in purple, and loses GTP. Adenylate cyclase converts ATP to cyclic AMP, which then activates Protein Kinase, shown in blue. Protein Kinase phosphorylates an ion channel, letting sodium ions rush into the cell.
As a result of the ligand binding to its site on the G-protein-linked receptor, A) the G-protein changes conformation and GTP replaces the GDP on the alpha subunit. ... Inactivation of the alpha subunit occurs when its own phosphorylase activity removes a phosphate from the GTP.
Cells are very different but have similar properties
Answer:
becomes accumulated in the blood
Explanation:
The processing of alcohol is constant in every individual. The rate at which alcohol stays in someone's body is determined by how much of it is consumed.
Alcohol enters the digestive system once ingested and travels to the stomach and small intestines. The amount of alcohol absorbed in the small intestine enters directly to the bloodstream. Once in the blood, alcohol is circulated with it. The liver is responsible for the metabolic elimination of most (about 95%) of ingested alcohol from the body. If an individual consumes more than this, the system becomes saturated, and the additional alcohol will accumulate in the blood and other tissues until it can be metabolized. If this happens frequently or too fast, damage to the brain and tissues of the body can occur.
Blood Alcohol Concentration (BAC) depends on the amount of alcohol consumed and the rate at which the individual's body metabolizes alcohol. Because the metabolism of alcohol by the body is constant, taking in alcohol at a rate higher than the rate of metabolizing it results in a cumulative effect and increase in the blood alcohol concentration.
It is important to note that, the more one drinks the longer alcohol stays in the system.
Equal and persevered transformed
