A mutation in human ATPase 6 from leucine to
arginine at position 156 may allow the movements of protons across the
membrane, but not rotating of the ring of c subunits.
This possible mechanism affect the function of
ATP synthase because there would be an uncoupling of proton translocation and ATP
synthesis. ATP synthase would remain sensitive to F0 proton conduction
inhibitors
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Donna's doctor diagnoses her with muscle cramps. Muscle cramps makes an individual suffer leg pain, in addition to this a person's calf muscles can contract involuntarily in which Donna is currently experiencing. Muscle cramps happen due to low fluid intake which could make a person experience this. In which could make muscles tighten, leading or giving pain to the individual.
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