C. Raphael, is a Renaissance painter who is known for his Madonnas and frescoes
The answer is A. A connection with world events.
I just picked it and got the answer right.
Whiskey Rebellion was the famous event
Meiji Constitution, constitution of Japan from 1889 to 1947. After the Meiji Restoration (1868), Japan's leaders sought to create a constitution that would define Japan as a capable, modern nation deserving of Western respect while preserving their own power. The resultant document, largely the handiwork of the genro (elder statesman) Itō Hirobumi, called for a bicameral parliament (the Diet) with an elected lower house and a prime minister and cabinet appointed by the emperor. The emperor was granted supreme control of the army and navy.
The halting of the advances of the ottoman Turks.