Some states with existing colonies strengthened their control over those colonies and in some cases assumed direct control over colonies previously held by non-state entities. European states as well as the United States and Japan acquired territories throughout Asia and the Pacific, while Spanish and Portuguese influence declined. Many European states used both warfare and diplomacy to expand their empires in Africa. Trade in some commodities was organized in a way that gave merchants and companies based in Europe and the U.S. a distinct economic advantage. The need for raw materials for factories and increased food supplies for the growing population in urban centers led to the growth of export economies around the world that specialized in commercial extraction of natural resources and the production of food and industrial crops. The profits from these raw materials were used to purchase finished goods. Increasing questions about political authority and growing nationalism contributed to anti-colonial movements. Anti-imperial resistance took various forms, including direct resistance within empires and the creation of new states on the peripheries. Increasing discontent with imperial rule led to rebellions, some of which were influenced by religious ideas.
Because it lay on the European side of the Strait of Bosporus, the Emperor Constantine understood its strategic importance and upon reuniting the empire in 324 CE built his new capital there -- Constantinople.
I do not believe the founding fathers of the American constitution set the foundation works for slavery and racism in the South with the ratification of the Three-Fifths compromise because, racism and slavery were already a major part of the 13 colony's, especially in the Southern state of Georgia.
Georgia was under a law that prohibited non-Native Americans from remaining on Indian reservations unless they had authorization from the state governor. Meanwhile, Georgia allowed white missionaries to remain on Indian reservations. This practice was mainly due to the discovery of gold in these territories, which caused a great uproar in Georgia.