The MC1R gene provides instructions for making a protein called the melanocortin 1 receptor. This receptor plays an important role in normal pigmentation. The receptor is primarily located on the surface of melanocytes, which are specialized cells that produce a pigment called melanin.
This is known as the diaphragm.
The translation, controlled destruction, mRNA turnover, and transcription of proteins all affect the proteotranscriptomic landscape.
- Extracellular vesicles (EVs) in circulation carry lipids, proteins, RNA, and DNA from the cell that produced them. As a result, EV-associated proteins and RNA have drawn a lot of attention as liquid-biopsy indicators.
- However, it is still unclear how the proteo-transcriptomic landscape of EVs compares to that of their cell of origin.
- The study present evidence that certain proteo-transcriptomes that are enriched by EVs do not linearly correlate with those that originate from those cells.
- Study demonstrate the enrichment of short RNA (13–200 nucleotides) involved in cell differentiation, development, and Wnt signaling as well as endosomal and extracellular proteins by EVs. RNY3, vtRNA, MIRLET-7, and the corresponding proteins YBX1, IGF2BP2, and SRSF1/2 are carried by EVs.
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