Ok, so I'm not sure if the man affected with fh has Ff alleles or FF alleles. However, I think by the question that he has Ff alleles. So there is a 50% chance that the offspring will be affected by fh.
Lysosomes remove waste at a cellular level.
They contain digestive enzymes, so they're like the digestive system.
The stomach digests food, so lysosomes could be considered like the stomach.
But then again, so do the intestines, small and large.
Since the stomach doesn't also work to remove waste though, I'd say the answer is probably large intestine, which finishes the digestive process and removes waste material.