All the spheres interact with other spheres. For example, rain (hydrosphere) falls from clouds in the atmosphere to the lithosphere and forms streams and rivers that provide drinking water for wildlife and humans as well as water for plant growth (biosphere).
Interleukin-5 (IL-5). IL-5 is responsible for the recruitment and maturation of eosinophil. Eosinophils on the other hand are majorly involved in the inflammatory response in asthma- characterised by narrowing of the airways. Mepolizumab and reslizumab are, therefore, anti-IL-5
Region A, Hope this helps.