Question

? In what way is androgen insensitivity syndrome similar to type 2 diabetes mellitus?

Answer 1

Answer:

Both disorders are caused by defects in hormone receptors, instead of lack of the respective hormone  

Explanation:

Androgen insensitivity syndrome is an X-chromosome-linked disorder in which a baby is unresponsive to male hormones (i.e., androgens) in the body. Androgen insensitivity is caused by mutations in genes that encode androgen receptors, thereby cells cannot respond to androgens (e.g., testosterone), which are required for male sexual development. Moreover, type 2 diabetes mellitus is a hormonal disorder observed in individuals that cannot respond to insulin, the main hormone that regulates the amount of glucose in the blood, and thereby individuals with this disorder exhibit elevated blood glucose levels. Mutations in the insulin receptor gene have also been identified in patients with type 2 diabetes. Therefore, both disorders are caused by defects in hormone receptors rather than from a lack of the respective hormone.