A feeling of distress, caused by loss or something else that has tragically happened.
Answer:
anxiety; mental uneasiness
Explanation:
Or a disturbance of motion, course, arrangement, or state of equilibrium especially : a disturbance of the regular and usually elliptical course of motion of a celestial body that is produced by some force additional to that which causes its regular motion.
I believe the answer is C. thorough.
It's all about context clues. Careful is most similar to thorough and makes the most sense.