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Biomolecules include large macromolecules (or polyanions) such as proteins, carbohydrates, lipids, and nucleic acids, as well as small molecules such as primary metabolites, secondary metabolites, and natural products. A more general name for this class of material is biological materials.
A larger, biologically active protein complex is created when two or more protein subunits come together to form a quaternary structure.
A protein's quaternary structure is formed when several protein chains or subunits come together in a compact configuration. There are separate primary, secondary, and tertiary structures for each of the subunits. Hydrogen bonds and van der Waals forces between nonpolar side chains hold the subunits together.
For a quaternary structure to function as a whole, the subunits must be arranged in a particular way. Any change to the subunits' structure or how they are linked results in noticeable adjustments in biological activity.
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Water through a cell membrane.