It becomes inactive in the stomach because of the stomach having a MUCH greater PH level then the mouth. It is typically 1.0-2.0 in the Stomach which is extremely acidic which causes it to change shape and therefore inactive.
Answer:
<h2>They provide a 3’ end for the DNA polymerase.</h2>
Explanation:
Polymerase chain reaction (PCR) is an in-vitro method to making copies of a specific DNA sample in a very short time.
Polymerase chain reaction was invented by Kary Mullis in 1983.
Primers are specific to the DNA which we want to replicate and they bind to the specific sequence which is complementary to it. Primers provide a 3’ end for the DNA polymerase.
Answer:
Monoclonal antibodies (mAbs) are produced by introducing an antigen to a mouse and then fusing polyclonal B cells from the mouse's spleen to myeloma cells. The resulting hybridoma cells are cultured and continue to produce antibodies to the antigen.
Explanation:
An example of a monoclonal antibody is blinatumomab (Blincyto, Amgen), used to treat certain cancer, types of acute lymphocytic leukemia.
Answer:
a mutation that blocks the GTPase activity of Ras
Explanation:
A G protein in inactive state is GDP bound but as soon as a guanine exchange factor (GEF) exchanges it with GTP it gets activated which means that in GTP bound state it is active. G - protein has endogenous GTPase activity. Upon interaction of GAP, the GTPase activity of this protein is exhibited. When GAP is present, hydrolysis of GTP into GDP occurs which leads to inactivation of G protein. A mutation which will block GTPase activity of Ras will therefore result in constitutive active signaling even in the absence of ligand binding to it's receptor. In such scenario, GTP will not be hydrolyzed into GDP so signaling will be up-regulated.
