Independent clause uses commas to separate independent clauses when they are joined by any of these seven coordinating conjunctions: and, but, for, or, nor, so, yet.
If it's just a random thesis:
Topic: Dog Fights
Thesis: Dog fights should be illegal, since they are a cruel way to abuse dogs for profit.
Opposing Thesis: Dog fights are entartaining, and should be continued.
Demetrius says "I love thee not therefore pursue me not" in A Midsummer Nights Dream, by William Shakespeare
