Answer:
Basically the translation of CK-B protein is inhibited in the U937D cells, despite the fact that the CK-B protein is bounded to the ribosomes. This is because(<u>mechanisms)</u> the translation is inhibited by the binding of translational repressors to the 3’UTR of the CK-B mRNA rather than the actual CK-B mRNA 3'UTR.
Furthermore, the soluble protein inhibitions is due to the reaction of the U937 cells to the short RNA sequences with the 3’UTR.
<u>The introduction of these sequences(shot segement of RNA) </u>into the U937D cells leads to CK-B synthesis. This makes 3’UTR sequences to bind to the translational repressor proteins, thus preventing them from binding to the CK-B mRNA
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COMPLETED QUE.
A common feature of many eukaryotic mRNAS is the presence of a rather long 3' UTR, which often contains consensus sequences. Creatine kinase B (CK-B) is an enzyme important in cellular metabolism. Certain cells—termed U937D cells—have lots of CK-B mRNA, but no CK- B enzyme is present. In these cells the 5’ end of the CK-B mRNA is bound to ribosomes, the mRNA is apparently not translated. Something inhibits the translation of the CK-B mRNA in these cells. Researchers introduced numerous short segments of RNA containing only 3’UTR sequences into U937D cells. As result, the U937D cells began to synthesize the CK-B enzyme, but the total amount of CK-B mRNA did not increase. The introduction of short segments of other RNA sequences did not stimulate the synthesis of CK-B; only the 3’UTR sequences turned on the translation of the enzyme. Based on these results, <u>purpose a mechanism for how CK-B translation is inhibited in U937D cells. Explain how the introduction of short segments of RNA containing the 3'UTR sequences might remove the inhibition.</u>
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Explanation:
Answer:
If the grasshopper is removed, the snakes will die, because the snakes have nothing to eat, and whatever eats snakes will die, and so on.
Answer:
to adopt a healthy lifestyle in order to prevent and/or reduce the risk of developing complex diseases
Explanation:
Complex genetic diseases are diseases that have a genetic basis but often don't show a clear pattern of inheritance, i.e., the genes that encode for the trait of interest are localized in quantitative trait <em>loci </em>(QTL). In general, complex genetic diseases are multifactorial because both genetic and environmental factors play important roles in the development of this type of disease. Some well-known examples of multifactorial genetic diseases include, among others, heart diseases, diabetes, asthma, some type of cancers, etc. It is well known that healthy lifestyle habits such as maintaining a healthy weight, eating healthy foods, avoiding harmful substances, etc., can prevent complex genetic conditions from manifesting.
