An individual inherits two defective copies of the MLH1 gene, a protein involved in mismatch repair of DNA during its replicatio

Question

Savatey [412]

3 years ago

8

An individual inherits two defective copies of the MLH1 gene, a protein involved in mismatch repair of DNA during its replicatio

n. What do you predict will be the consequence of deficient mismatch repair upon DNA replication?

Biology

1 answer:

Lunna [17] · Answer 1 · 2022-08-09T17:03:35+03:00

Answer:

New mutations will become permanent

Explanation:

Human MutL homolog 1 (MLH1) gene is a well-known tumor suppressor gene that encodes for a DNA mismatch repair protein. The MLH1 protein is part of the DNA mismatch repair (MMR) genetic system which recognizes and repairs the incorrect addition of nucleotides during DNA replication and recombination. It has been shown that inherited mutations in one allele of the MLH1 gene increase the risk of cancer, especially colorectal cancer.