Secretin increases the flow of bicarbonate ions from the pancreas into the small intestine to neutralize stomach acid.
Gastric acid regulation, pancreatic bicarbonate modulation, and osmoregulation are the three primary roles of secretin. Pancreatic fluid stimulation and bicarbonate secretion are two of secretin's main physiological effects.
Peptide hormones released by endocrine cells in the digestive system include secretin and CCK. While CCK enhances the synthesis and secretion of bile juice and pancreatic enzymes, Secretin stimulates the release of water and bicarbonate ions from the pancreas.
A pancreatic fluid that is high in bicarbonate is secreted when secretin is present. By interacting with pancreatic ductal cells, secretin enters the bloodstream or intestinal lumen and increases the production of bicarbonate, which lowers the pH of the gastric chyme as it enters the small intestine.
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