The Us were able to find same Cuban products from other supplier countries, while the Cuban country had to find other suppliers.
Cuba was not able to develop a high commerce with the US and the surrounding countries were not necessarily the best ones to make business with. Cuba had the support from the former USSR until 1989 when it was dissolved. Russia continued helping but not at the same level or amount as before.
The main idea of the Trail of Tears in 1838 and 1839 was to force the Cherokee nation to give up its land in the Mississippi river and migrate to present Oklahoma, as part of Andrew Jackson's Indian removal policy, this way the white settlers could grow cotton on the Indians land. It is important to learn about it to enforce the laws and protect the rest of the indigenous civilization in modern days