The nurse is providing education regarding drug distribution to a patient. the factors affect drug distribution in the body are: -
a) Amount of blood flow to the body tissues
c) Medications being fat or water soluble
Factors Influencing the Distribution of Drugs
Vengamma Ramineni
2020 Tuesday, October 6
The medications are put through a series of procedures known as disposition processes, which have the tendency to reduce the drug's plasma concentration.
The procedures for drug disposal are:
1. Distribution - In this process, a medication is transferred reversibly across compartments.
2. Elimination - In this process, the medication is permanently removed from the body by biotransformation and excretion.
Definition
The reversible transport of a drug from one compartment (blood) to another is known as drug distribution (extravascular tissue).
The gradient in concentration between the blood and extravascular tissues drives distribution, which is a passive process.
Diffusion of the free drug causes this process to continue until equilibrium is reached.
These activities are involved in drug distribution two steps:
Free medication in the blood passes past the capillary wall and enters the interstitial/extracellular fluid (ECF).
Drugs can pass through tissue cell membranes and into intracellular fluid (ICF) from extracellular fluid (ECF). This process is rate-limited and is affected by two variables:
the ECF's rate of perfusion, and
Drug Permeability across Membranes.
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