by performing a bioinformatic analysis in order to discover Y chromosome-linked mutations associated with defective phenotypes. In this case, it is expected to discover two or more loss of function mutations located in the coding region of the target gene on the Y chromosome in different males, and then associate such mutations with altered phenotypes caused by the inactivation (loss of function) of this gene
Explanation:
The genes located on the Y chromosome exhibit a uniparental mode of inheritance (i.e., these genes are only transmitted from father to their sons). This situation makes difficult to map the target gene since recombination does not occur for genes that are only located on the Y chromosome, hampering the development of a linkage map containing this gene. In this case, it is possible to directly associate genetic mutations located at the same genomic region (<em>locus</em>) on the Y chromosome with a particular altered phenotype in males carrying these mutations, which can be in principle associated with the inactivation of the target gene (loss of function mutations) in these individuals.
The reticular layer of the dermis (RD) consists of dense irregular connective tissue, which differs from the papillary layer (PD), which is made up of mainly loose connective tissue (note the difference in the number of cells).
<span>Vitamin B6 will be administered to prevent inh associated peripheral neuropathy. Vitamin B6 can help with peripheral nueropathy, since it can relieve the pain from nerve damage, but the nurse must be careful. Too much vitamin B6 can have the opposite effect and cause nerve damage or numbness.</span>
Cool air produces high air pressure and warm air produces low air pressure. it will affect pressure and cause wind when warm air rises and cool air moving in which will replace the warm air